Welcome to VOLPES!

A tool to visualize physicochemical sequence properties of biological macromolecules.

visualization of physicochemical sequence properties: VOLPES

Structure, dynamics and, ultimately, biological function of proteins and nucleic acids are determined by the physicochemical properties of their primary sequences. Such properties are frequently captured via one-dimensional profile plots depicting a given physicochemical variable as a function of sequence position. Here, we present VOLPES, a user-friendly webserver and the associated JavaScript library that enable a fully interactive, multifunctional visualization, analysis and comparison of the physicochemical properties of protein and nucleic-acid sequences, allowing unprecedented insight into raw sequence data and creating a starting point for further in-depth exploration. Over 600 different amino acid and nucleobase properties are available through the interface (many sourced from the AAIndex [1]) to get your analysis started right away.

Start the analysis!


Are you a new user or a returning user who wants some additional instructions? We set up a tutorial page for you explaining the usage of VOLPES in detail.

To the tutorial


Fancy a real-world illustration of VOLPES in action? Check out these interactive examples, play around and get a feel for what this tool is all about!

Try it out